Department of Immunobiology

Arizona Cancer Center Room 6112
P.O. Box 245049
Tucson, AZ 85724-5049
Phone: 626-6069

Fax: 626-2100
E-mail: bernstein3@earthlink.net

EDUCATION:

California Institute of Technology, 1961 (Ph.D.)

MAJOR AREAS OF RESEARCH INTEREST:

-DNA damage and programmed cell death (apoptosis) in colon cancer
-Molecular basis of sexual reproduction and aging.
-Role of bile acid induced DNA damage and programmed cell death

SELECTED PUBLICATIONS:

Bernstein H. Payne CM. Kunke K. Crowley-Weber CL. Waltmire CN. Dvorakova K. Holubec H. Bernstein C. Vaillancourt RR. Raynes DA. Guerriero V. Garewal H. A proteomic study of resistance to deoxycholate-induced apoptosis. Carcinogenesis. 25(5):681-92, 2004.

Crowley-Weber CL. Dvorakova K. Crowley C. Bernstein H. Bernstein C. Garewal H. Payne CM. Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. Chemico-Biological Interactions. 145(1):53-66, 2003.

Romagnolo DF. Chirnomas RB. Ku J. Jeffy BD. Payne CM. Holubec H. Ramsey L. Bernstein H. Bernstein C. Kunke K. Bhattacharyya A. Warneke J. Garewal H. Deoxycholate, an endogenous tumor promoter and DNA damaging agent, modulates BRCA-1 expression in apoptosis-sensitive epithelial cells: loss of BRCA-1 expression in colonic adenocarcinomas. Nutrition & Cancer. 46(1):82-92, 2003.

Garewal H. Ramsey L. Fass R. Hart NK. Payne CM. Bernstein H. Bernstein C. Perils of immunohistochemistry: variability in staining specificity of commercially available COX-2 antibodies on human colon tissue. Digestive Diseases & Sciences. 48(1):197-202, 2003.

Crowley-Weber CL. Dvorakova K. Crowley C. Bernstein H. Bernstein C. Garewal H. Payne CM. Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. Chemico-Biological Interactions. 145(1):53-66, 2003.

SPONSORED RESEARCH THROUGH MSRP:

Beth Minzter (MSRP 1998): "Effect of starvation on recombination in Phage T4."

Last update: 7/12/2006