Robert S. McCuskey, Ph.D.

Department Head and Professor Emeritus, Cell Biology and Anatomy
Member, Bio5 Institute

Department of Cell Biology and Anatomy
AHSC 4205
P.O. Box 245044
Tucson AZ 85724-5044

Phone: (520)626-6084    
E-mail: mccuskey@aruba.ccit.arizona.edu
or
mccuskey@email.arizona.edu

EDUCATION:

Case Western Reserve University, 1965 (Ph.D.)

HONORS/AWARDS:

-Research Career Development Award, National Institute of Arthritis and Metabolic Diseases, N.I.H., July 1, 1969 - June 30, 1974
-Alexander von Humboldt Stiftung, Senior U.S. Scientist Prize from the Federal Republic of Germany, March 1982 (for outstanding achievement in high resolution in vivo microscopy of organs)
-Eugene M. Landis Research Award, the Microcirculatory Society's top award to an established investigator, 2004.

MAJOR AREAS OF RESEARCH INTEREST:

Microscopic anatomy, physiology, pharmacology and pathology of living cells, tissues and organs in situ, particularly as related to the microvasculature of the liver and hemopoietic organs; application of electronic imaging techniques to microscopic study of living cells, tissues and organs in situ; development and use of fluorescent probes and spectrophotometry to study cellular function in intact organs using high resolution in vivo microscopic methods. Research of the past several years has focused on the interactive role of endotoxin and Kupffer cells in host defense mechanisms and pathophysiology of the liver induced by alcohol and/or infection.

STUDENT OPPORTUNITIES THROUGH RESEARCH:

Wide variety of research projects involving study of the effects of endotoxin, alcohol, sepsis and viral infection alone or in combination on hepatic microvascular structure and function.-Use of state of the art light and electron microscopic imaging techniques-International and national collaborations with potential for travel to other laboratories and scientific meetings.

SELECTED PUBLICATIONS

Hasegawa T, Ito Y, Wijeweera J, Liu J, Malle E, Farhood A, McCuskey RS, Jaeschke H. Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of OB/OB mice. Am J Physiol Gastrointest Liver Physiol. 2007 Feb 15; [Epub ahead of print] PMID: 17307725.

Ito Y, Doelle SM, Clark JA, Halpern MD, McCuskey RS, Dvorak B. Intestinal microcirculatory dysfunction during the development of experimental necrotizing enterocolitis. Pediatr Res. 61(2):180-4, 2007.

Ito Y, Lugea A, Pandol SJ, McCuskey RS. Substance P mediates cerulein-induced pancreatic microcirculatory dysfunction in mice. Pancreas. 34(1):138-43, 2007.

Ito Y, Abril ER, Bethea NW, McCuskey MK, Cover C, Jaeschke H, McCuskey RS. Mechanisms and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice. Am J Physiol Gastrointest Liver Physiol. 291(2):G211-8, 2006.

Last updated: 3/20/2007