Ray B. Nagle, M.D., Ph.D.
Emeritus Professor, Pathology

Director, MD/PhD Program

Department of Pathology

AHSC 5208
P.O. Box 245043
Tucson AZ 85724-5043
Phone: 626-6109 or 626-2490
E-mail: rnagle@email.arizona.edu

EDUCATION:

University of Washington, 1964 (M.D.)

University of Washington, 1965 (Internship)

University of Washington 1965-70 (Residency)

University of Washington, 1967 (Ph.D.)
University of Washington 1967-70, (Post-Doctoral,Experimental Pathology )

HONORS/AWARDS:

Arthur Purdy Stout Lecturer, 1987
Alumni Achievement Award, Washington State University, 1989
Louis J. Kettel Faculty Mentor Award, Basic Sciences Mentor, Medical Student Research Program, 1994

MAJOR AREAS OF RESEARCH INTEREST:

1. Cytoskeletal proteins

2. Prostate carcinogenesis

SELECTED PUBLICATIONS:

Pawar SC, Demetriou MC, Nagle RB, Bowden GT, Cress AE.  Integrin alpha6 cleavage: A novel modification to modulate cell migration. Exp Cell Res. Jan 17, 2007; PMID: 17303120.

Ignatenko NA, Holubec H, Besselsen DG, Blohm-Mangone KA, Padilla-Torres JL, Nagle RB, de Alboranc IM, Guillen-R JM, Gerner EW. Role of c-Myc in Intestinal Tumorigenesis of the Apc(Min/+) Mouse. Cancer Biol Ther. 5(12):1658-64, 2006.

Kremer CL, Klein RR, Mendelson J, Browne W, Samadzedeh LK, Vanpatten K, Highstrom L, Pestano GA, Nagle RB. Expression of mTOR signaling pathway markers in prostate cancer progression. Prostate. 66(11):1203-12, 2006.

Calaluce R. Beck SK. Bair EL. Pandey R. Greer KA. Hoying AM. Hoying JB. Mount DW. Nagle RB. Human laminin-5 and laminin-10 mediated gene expression of prostate carcinoma cells. Prostate. 66(13):1381-90, 2006 .

Kidd KR, Dal Ponte D, Stone AL, Hoying JB, Nagle RB, Williams SK. Stimulated endothelial cell adhesion and angiogenesis with laminin-5 modification of expanded polytetrafluoroethylene. Tissue Eng. 11(9-10):1379-91, 2005.

Bair EL, Nagle RB, Ulmer TA, Laferte S, Bowden GT. 90K/Mac-2 binding protein is expressed in prostate cancer and induces promatrilysin expression. Prostate. 66(3):283-93, 2006.

Bair EL, Chen ML, McDaniel K, Sekiguchi K, Cress AE, Nagle RB, Bowden GT.
Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration. Neoplasia. 7(4):380-9, 2005.

Buschhorn HM, Klein RR, Chambers SM, Hardy MC, Green S, Bearss D, Nagle RB. Aurora-A over-expression in high-grade PIN lesions and prostate cancer. Prostate. 64(4):341-6, 2005.

STUDENT OPPORTUNITIES THROUGH RESEARCH:

First-hand experience in immunohistochemistry, antibody development and characterization

SPONSORED RESEARCH THROUGH MSRP:

Eric Altschuler (MSRP 1981): "Biochemical characterization of a macrophage growth factor."

Mindy Fuchs-Lokshin (MSRP 1986): "A comparison of immunocytologic staining, flow cytometry, and conventional Wright/Giemsa staining for the detction and analysis of prostate cancer."

Mindy Fuchs-Lokshin (MSRP 1987-1988): "Immunohistochemical study of human prostatic basement membrane. Relationship of basement membrane to histologic grade of human prostatic carcinoma."

Hoang Minh Thai (MSRP 1988): "Intraductal dysplasia as a symptomatic marker in prostate cancer."

Kurt Heiland (MSRP 1989): "Stratification of node negative breast cell carcinoma patients on the basis of HER-2-NEW gene product."

Diana Friedman (MSRP 1991): "Studies in prostate carcinoma progression, invasion and metastasis."

Heather E. Coates (MSRP 1992): "Cytokeratin expression in cell lines with different amounts of "6 integrin and in cells isolated from prostate cancer."

Diana Friedman Koss (MSRP 1991-1992): "Studies in Prostate Carcinoma Progression, Invasion and Metastasis."

Paul Fanta (MSRP 1998, 2000): "A Correlation of Prostate Sexant Biopsy Studies with Cancer Progression."

Sarah Chiang (MSRP 2004): "Characterization of extracellular matrix proteins involved in perineural invasion in prostate cancer."

Mark Zubriski (MSRP 2004): "Determination of Wild Type Versus Cleaved Laminin 5 and 10 on Gene Expression in Human Prostate Tumor Progression."

NIH HIGH SCHOOL STUDENT RESEARCH PROGRAM:

-Bernadette A. Bova, Santa Rita High School, 1990
-Vanessa Godoy, Flowing Wells High School, 1993
-Claudia Ibarra, Pueblo High School, 1994
-Cody Miller-Montijo, Pueblo High School, 1995
-Veronica Gutierrez, Flowing Wells High School, 1996
-Nikita M. Patel, Willcox High School (Willcox, AZ), 1998
-James Slinkey, Window Rock High School (Window Rock, AZ), 2004
-Dohyung Kwon, Gilbert High School (Gilbert, AZ), 2006

NIH K-12 SCIENCE TEACHER RESEARCH PROGRAM:

-Tamara Lynch, La Cima Middle School, 1995
-Denise Cluff, Pueblo High School, 1996

Last updated: 3/21/2007