Department of Medicine

Sarver Heart Center 4143f
P.O. Box 245037
Tucson AZ 85724-5037
Phone: 626-6221
E-mail: wroeske@email.arizona.edu

EDUCATION:

Stanford University, 1970 (M.D.)
Case Western Reserve, 1970-1971 (Internship)
Case Western Reserve, 1971-1973 (Residency)

Case Western Reserve, 1973-1976 ( Cardiology Fellowship)

HONORS/AWARDS:

Membership in American Society of Clinical Investigators

MAJOR AREAS OF RESEARCH INTEREST:

Cardiac receptors in growth and hypertrophy. We will investigate alterations of receptors in experimental models of hypertension or in development. Echo-Doppler correlates congestive heart failure. We will examine alterations in measurable velocities and blood flow in normal vs. patients with congestive heart failure in carefully controlled clinical studies.

SELECTED PUBLICATIONS:

Navratilova E. Eaton MC. Stropova D. Varga EV. Vanderah TW. Roeske WR. Yamamura HI. Morphine promotes phosphorylation of the human delta-opioid receptor at serine 363. European Journal of Pharmacology. 519(3):212-4, 2005.

Varga EV. Hosohata K. Borys D. Navratilova E. Nylen A. Vanderah TW. Porreca F. Roeske WR. Yamamura HI. Antinociception depends on the presence of G protein gamma2-subunits in brain. European Journal of Pharmacology. 508(1-3):93-8, 2005.

Huang MH. Bahl JJ. Wu Y. Hu F. Larson DF. Roeske WR. Ewy GA. Neuroendocrine properties of intrinsic cardiac adrenergic cells in fetal rat heart. American Journal of Physiology - Heart & Circulatory Physiology. 288(2):H497-503, 2005.

Varga EV. Navratilova E. Stropova D. Jambrosic J. Roeske WR. Yamamura HI. Agonist-specific regulation of the delta-opioid receptor. Life Sciences. 76(6):599-612, 2004.

RESEARCH ACTIVITIES:

Cardiovascular pharmacology of autonomic receptor drugs; molecular biology of five types of receptors with specific drugs; correlation of the development of the beta adrenergic receptor and other postreceptor mechanisms in the developing heart; noninvasive evaluation of left ventricular function and performance; differences between muscarinic receptors in the heart and other tissues.

STUDENT OPPORTUNITIES THROUGH RESEARCH:

We are interested in students who are committed to doing a research project. We have an ongoing laboratory in which several individuals can provide help and assistance.

SPONSORED RESEARCH THROUGH MSRP:

Ronald Evans (MSRP 1983): "Muscarinic receptors in growth and development."
Richard Heck (MSRP 1988): "Cholinergic antagonists identify a subclass of the muscarinic receptor gene family in human pancreatic carcinoma cells."

Last updated: 6/28/2006