Richard Whalen, Ph.D.

Research Assistant Professor, Medicine

Department of Medicine
Liver Research Institute
AHSC 6310b
P.O. Box 245136
Tucson, AZ 85724-5136

Phone: 520 626-5874
Fax: 520 626-5975
e-mail: rwhalen@u.arizona.edu

EDUCATION:

University of Georgia, 1984 (M.S., Zoology)
University of Delaware, 1990 (Ph.D., Biological Sciences)
Emory University, 1991-1992 (Post-doctoral training)

RESEARCH INTERESTS:

Structure, function, and regulation of liver glutathione transferases in pathophysiology. Structure, function, and regulation of transcription factors HNF1 and USP3 (and others) involved in the regulation of glutathione transferases and other liver-specific genes during pathophysiology such as sepsis.

SELECTED PUBLICATIONS:

Whalen R. Liu X. Boyer TD. Identification of a short form of ubiquitin-specific protease 3 that is a repressor of rat glutathione S-transferase gene expression. Biochemical Journal. 394(Pt 2):519-26, 2006.

Ranganathan PN. Whalen R. Boyer TD. Characterization of the molecular forms of glutathione S-transferase P1 in human gastric cancer cells (Kato III) and in normal human erythrocytes. Biochemical Journal. 386(Pt 3):525-33, 2005.

Whalen R. Voss SH. Boyer TD. Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP. Biochemical Journal. 377(Pt 3):763-8, 2004.

Voss SH. Whalen R. Boyer TD. Mechanism of negative regulation of rat glutathione S-transferase A2 by the cytokine interleukin 6. Biochemical Journal. 365(Pt 1):229-37, 2002.

STUDENT OPPORTUNITIES THROUGH RESEARCH:

We offer high-priority laboratory research projects that are in the main line of our research efforts and therefore require intense participation. Participation generally involves inclusive interaction with several active researchers and investigators working concurrently on several related projects.

SPONSORED THROUGH MSRP:

Jaskanwal Singh (MSRP 2006, 2007): "DNA binding region of ubiquitin specific protease 3."